nestedlist = [[1, 2, 3], [1, 5], [6, 1, 8, 9, 10], [9, 27, 1, 85], [1]]
for i1, sub_list in enumerate(nestedlist):
for i2, element in enumerate(sub_list):
if element == 1:
nestedlist[i1][i2] = 777
print(nestedlist)
'''
run:
[[777, 2, 3], [777, 5], [6, 777, 8, 9, 10], [9, 27, 777, 85], [777]]
'''