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lst = [[4, 3, 5], [7, 5, 8], [3, 1, 6], [5, 9, 3], [1, 4, 2], [6, 9, 1]] last_index = len(lst[0]) - 1 lst.sort(key=lambda x: x[last_index], reverse=True) print(lst) ''' run: [[7, 5, 8], [3, 1, 6], [4, 3, 5], [5, 9, 3], [1, 4, 2], [6, 9, 1]] '''